(620) First Report of the Transmedics Organ Care System Heart Perfusion Registry. A Multi-Institutional Outcomes Analysis

PurposeExtracorporeal organ perfusion promises to substantially increase the use of donor organs. The TransMedics Organ Care System Heart (OCS) has received FDA approval for in expanded criteria donation after brain death (DBD) and circulatory (DCD). OHP Registry aims document post-approval practices outcomes.MethodsWe examined a contemporary observational multi-center registry transplant recipients OCS instrumented hearts (OCS group) standard cold storage DBD (Control transplanted at same centers over period time. Data sources were US UNOS database.ResultsBetween September 2021 2022, 636 patients heart 28 that OCS. Of these, 412 underwent storage, 224 236 on utilization rate was 94.9% 35.2% all transplants using resulted from organs perfused At submission, data 150 (60 DBD, 90 DCD), 285 Control group are available Registry. Baseline characteristics shown Table 1ABC. Donor-recipient hospital distance longer groups compared higher proportion (48%) DCD (70%) Status 3-6 (31%). 1D shows incidence primary graft dysfunction (PGD). Survival 6 months similar - Figure 1.ConclusionOne third participating hearts. more commonly allocated lower urgency status patients, indicating improved access transplantation with Despite numerically greater PGD among vs survival these storage. Extracorporeal outcomes. We database. Between 1. One